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relapsed refractory multiple myelomadouble refractory multiple myelomarefractory myelomaselinexor multiple myelomamultiple myeloma relapse treatmentrelapsed refractory myelomasalvage therapy multiple myelomarrmm myelomaselinexor myelomarelapsed myeloma treatmentisatuximab multiple myelomasymptomatic multiple myeloma