polycythemia vera signs and symptomspolycythemia vera complicationssecondary polycythemia verapolycythemia vera myelofibrosispolycythemia vera diagnosispolycythemia vera hereditarypolycythemia vera prognosisdefine polycythemia veraprimary polycythemia verapolycythemia vera natural treatmentpolycythemia vera mutationpolycythemia vera meaning