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metastatic multiple myeloma prognosisaggressive multiple myeloma prognosismultiple myeloma relapse prognosissmoldering multiple myeloma prognosismyeloma treatment and prognosisstage 4 multiple myeloma prognosismultiple myeloma cancer survival ratemalignant myeloma prognosisasymptomatic myeloma prognosissmouldering myeloma prognosissmoldering myeloma prognosismyeloma prognosis in the elderly